Harmony Non-Invasive Prental Test - NIPT from 10 weeks of pregnancy 

  • Appointments available every day, including evening and weekends
  • Detailed ultrasound scan included by our Advanced Sonographer
  •  Includes an Early Fetal Ultrasound Scan, Early Anatomy Ultrasound Scan or Anomaly scan (dependent on gestation at time of appointment) by our Advanced Sonographers
  • Result in 3-10 calendar days.
  • Can be performed from 10 weeks
  • Electronic transmission of scan to your email via YourBabyScan
  • Optional sex determination included in the price


What is the Harmony test?

It has been discovered that a blood sample taken from the mother can be analysed for cell free fetal DNA, which is essentially a marker in the mother’s blood of the DNA of the baby. The result of the simple blood test (Harmony NIPT), taken from 10 weeks onwards has a high sensitivity for the detection of Downs syndrome, Edwards syndrome and Patau’s syndrome, which may reduce the need for invasive testing by CVS or amniocentesis. This is great news for expectant couples. It is important that an ultrasound scan is performed just before the blood test to confirm the pregnancy, and to check if the mother is carrying twins or more. The Harmony test can also be performed for twin pregnancies and can now be used if the pregnancy is conceived with donated egg.

Why the Harmony test?

This is one of the most accurate non invasive prenatal tests to detect the chance of a chromosomal condition in a pregnancy.

For the last ten years doctors have been using the results of the Nuchal Translucency Scan to advise pregnant women and their partners on their probability of having a baby with Downs syndrome, or other conditions. The Nuchal Translucency Scan looks at the skin fold on the back of the baby’s neck at about 12 weeks. This has been further refined by looking at the nose bone of the baby with an additional blood test to identify two pregnancy hormones.

This is the combined test and has achieved a positive predictive value of about 84%. Women with a high probability have an option to proceed to chorion villous sampling (CVS) or amniocentesis. These are invasive tests that carry a miscarriage risk of about 1:100 or less. 

harmony Pre natal test

Who needs Harmony Test?

Couples who are anxious about their baby having a chromosomal condition such as Downs, Edwards or Patau's syndrome, Women who need it are those who are older (particularly over 40 years), those who have already had chromosomal condition in a previous pregnancy or who are at particular risk of miscarriage should they have an amnioncentesis or chronic villious sample (CVS). 

  • The mother has to read and sign a consent form. 
  • An ultrasound scan is always performed first.
  • This is a simple blood test from the vein in the woman's arm like any other blood test. There is no risk from having this test.
  • Two blood sample tubes need to be collected.
  • The blood sample tubes are immediately packaged and sent to The Doctors Laboratory in London, improving turn around time.

How long does it take to get a result?

The result is available within 3-10 calendar days, the normal turnaround time is 5 working days. There is a 5% chance that there will be no result obtained. There are a variety of reasons for this. If the test is unsuccessful, an offer of a repeat test is made free of charge. We understand it can be a stressful time waiting for results and we will endeavour to communicate any delays to our patients as soon as we receive information from the laboratory.

How is the result expressed?

The result is expressed as a probability. This is not a positive or negative test: it is a screening test and not a diagnostic test. An example of a low probability test is shown below. A low probability test result gives a probability of a chromosomal problem of less than 1:10000. A high probability result does not confirm that the baby has the targeted chromosomal condition. An amniocentesis or chorionic villous sampling (CVS) is necessary to give a diagnosis. Genetic counselling is recommended in the case of a high probability result. 

> Example 1 - Low Probability Harmony NIPT Report

> Example 2 - High Probability Harmony NIPT Report

How much does it cost?

The Harmony Test costs £500. Appointments after 5pm, weekends and bank holidays incur a £50 surcharge. 
Included with every NIPT is an ultrasound by one of our Advanced Sonographers. 
NIPT appointments are available with the Consultant on Thursday afternoons. There will be an additional charge of £150.  

What happens after the test?

Depending on how many weeks pregnant you are, we recommend that you take the opportunity to have a 12 week scan privately or with the NHS. The focus of the 12 week scan will change as you will already have the result of the Downs syndrome test, so the 12 week scan will look at the baby in detail for structural conditions (these may exist without a chromosomal condition). The next routine ultrasound scan performed privately, or within the NHS, is the 20 week anomaly scan. If the Harmony test is low probability, then it is important that the person conducting the 12 week scan is aware of this. If the test is high probability then you should return to The Birth Company or your NHS unit for further counselling.

Many patients choose to upgrade to the comprehensive Gold Package - 
Click Here for more details.

Are there problems this test will not detect?

Yes. Structural conditions such as Spina Bifida, heart defects and a poorly growing baby will only be seen on ultrasound scans, often not until the second or third trimester. 

This new test has been developed by Ariosa Diagnostics www.ariosadx.com and is quality controlled by Ariosa Diagnostics.

TBC Recommends

Gold package with our Sonographer - Click Here for more details.


Please note in the circumstance that during your appointment an ultrasound scan is performed but we do not proceed to the NIPT, a fee of £120 (£180 for evening/weekend appointments) will be charged for the appointment only. If booked online, £380 will be refunded to you.

Please note Anticoagulation therapy (commonly called blood thinners) can increase the possibility of receiving No Result for your NIPT. Please leave as long between administering your dose and your NIPT appointment as possible. For example, if you administer in the evening and have an early morning appointment, either change to an appointment late in the day, or refrain from your evening dose. If you administer in the morning, refrain from that dose until after your appointment. If you have any queries regarding this, please contact our team admin@thebirthcompany.co.uk.

For further information please see below:
Anticoagulation Therapy Publication


Pregnancy Ultrasound Scans Available

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