Harmony NIPT (10-40 Weeks)

£50 Off

  • Appointments every day including weekends.
  • Detailed ultrasound scan included.
  • Result can take anything between 3 - 10 days
  • Electronic transmission of scan to your email.
  • Gender determination included in price (optional)


What is the Harmony test?

It has been discovered that a blood sample taken from the mother can be analysed for cell free fetal DNA, which is essentially a marker in the mother’s blood of the DNA of the baby. The result of the simple blood test (Harmony NIPT), taken from 10 weeks onwards has a high sensitivity for the detection of Downs syndrome, Edwards syndrome and Patau’s syndrome, which may reduce the need for invasive testing by CVS or amniocentesis. This is great news for expectant couples. It is important that an ultrasound scan is performed just before the blood test to confirm the pregnancy, and to check if the mother is carrying twins or more. The Harmony test can also be performed for twin pregnancies and can now be used if the pregnancy is conceived with donated egg.

Why the Harmony test?

This is one of the most accurate Non-Invasive Prenatal Tests to detect the chance of a chromosomal condition in pregnancy.

For the last ten years doctors have been using the results of the Nuchal Translucency Scan to advise pregnant women and their partners on their risk of having a baby with Downs syndrome, or other conditions. The Nuchal Translucency Scan looks at the skin fold on the back of the baby’s neck at about 12 weeks. This has been further refined by looking at the nose bone of the baby with an additional blood test to identify two pregnancy hormones.

This is the combined test and has achieved a positive predictive value of about 84%. Women with a high probability have an option to proceed to chorion villous sampling (CVS) or amniocentesis. These are invasive tests that carry a miscarriage risk of about 1:100 or less. 

harmony Pre natal test

Who needs Harmony Test?

Anyone who wants extra reassurance during their pregnancy can have the test. Women who may need it are those who are anxious about their baby having a chromosomal condition such as Downs, Edwards or Patau's syndrome, Older women (particularly over 40 years) and those who have already had a chromosomal condiition in a previous pregnancy often opt for the test. Those who are at particular risk of miscarriage should they have an amniocentesis or chorionic villous sample also find the test very attractive as it avoids an invasive procedure. It is helpful for those who have had a previous sex chromosome condition such as Turners syndrome.

  • The mother has to read and sign a consent form and sign a form for data release.
  • An ultrasound scan is always done first.
  • This is a simple blood test from the vein in the woman's arm like any other blood test. There is no risk from having the test.
  • Two tubes need to be fully filled.
  • The tubes are immediately packaged and sent to The Doctors Laboratory in London improving turn around time.

How long does it take to get a result?

The result is available within 3-10 working days, the normal turnaround time is 5 working days. There is a 3% chance that there will be no result obtained. There are a variety of reasons for this. This is not a positive or negative test: it is an unsuccessful test. An offer of a repeat test is made free of charge. This is usually successful. In rare circumstances the result can take longer than 7 days. We understand it can be a stressful time waiting for results and we will endeavour to communicate any delays to our patients as soon as we receive information from the laboratory.

How is the result expressed?

The result is expressed as a probability. It is a screening test and not a diagnostic test. A result form of a low probability test is shown below. A low probability test result gives a probability of a chromosomal problem of less than 1:10000. A high probability result gives a probability of greater than 99%. A high probability result does not confirm that the baby has the chromosome abnormality. An amniocentesis or chorionic villous sampling is necessary to give a diagnosis. The couple are counselled about this.

> Example 1 - Low Probability Harmony NIPT Report

> Example 2 - High Probability Harmony NIPT Report

How much does it cost?

The test is currently £500 including the ultrasound scan when done on a weekday. Appointments after 5.00pm will carry a £50 surcharge. If you would like to come in on a Saturday or Sunday the cost is £550.

What happens after the test?

Depending on how many weeks pregnant you are, you will still have the opportunity to have a 12 week scan privately or with the NHS. The focus of the 12 week scan will change as you will already have the result of the Downs syndrome test, so the 12 week scan will look at the baby in detail for structural conditions (these may exist without a chromosomal condition). You will still have the opportunity to have the later scans, such as the 20 weeks scan, as before. If the Harmony test is low probability then it is important that the person conducting the 12 week scan is aware of this. If the test is high probability then you should return to The Birth Company or a good NHS unit for further counselling.

Are there problems this test will not detect?

Yes. Structural abnormalities such as Spina Bifida, heart defects and a poorly growing baby will only be seen on scans and often not until later scans. These scans should still be undertaken.

This new test has been developed by Ariosa Diagnostics www.ariosadx.com and is quality controlled by Ariosa Diagnostics.




The Birth Company
Alderley Edge Medical Centre, Talbot Road, Alderley Edge SK9 7HR
For all bookings at Alderley Edge please call on 01625 704080
Nearest National Rail Station

Alderley Edge

Opening Times
Monday TBC
Tuesday 10:00 - 17:00
Wednesday 12:30 - 16:30
Thursday-Friday 10:00 - 14:00
Saturday TBC

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